Plant Transcription Factor Database
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G46768.1
Common NameERF006, F2G19.32, RAP2-1, RAP2.1
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 153aa    MW: 17240.6 Da    PI: 9.8152
Description related to AP2 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G46768.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2  2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                  y+G+r++k +g+WvAeIr+p   +kr r +lg++ t   Aa+a++ a  +l+g
                 69****998.**********9...336*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5103223.0113087IPR001471AP2/ERF domain
SuperFamilySSF541711.24E-203088IPR016177DNA-binding domain
SMARTSM003803.0E-353093IPR001471AP2/ERF domain
PRINTSPR003673.8E-123142IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.102.7E-303188IPR001471AP2/ERF domain
PfamPF008477.1E-123179IPR001471AP2/ERF domain
CDDcd000184.18E-263189No hitNo description
PRINTSPR003673.8E-126989IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009409Biological Processresponse to cold
GO:0009414Biological Processresponse to water deprivation
GO:0009873Biological Processethylene-activated signaling pathway
GO:0042538Biological Processhyperosmotic salinity response
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0001078Molecular Functiontranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677Molecular FunctionDNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000293anatomyguard cell
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 153 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
No. Start End Sequence
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.286760.0inflorescence| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT1G46768-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed at low levels in flowers, leaves, and stems, and at very low levels in roots. {ECO:0000269|PubMed:9192694}.
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the DREB subfamily A-5 of ERF/AP2 transcription factor family (RAP2.1). The protein contains one AP2 domain. There are 16 members in this subfamily including RAP2.9 and RAP2.10.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. RAP2.1 is a DREB-type, EAR-motif-containing transcriptional repressor that negatively regulates plant responses to cold and drought stresses.
    [PMID: 20230648]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT1G46768 (R), AT4G25470 (A), AT4G25480 (A), AT4G25490 (A)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G46768(R), AT2G42540(R), AT5G52310(R)
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G46768
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0838350.0AC083835.5 Arabidopsis thaliana chromosome 1 BAC F2G19 genomic sequence, complete sequence.
GenBankAY0868380.0AY086838.1 Arabidopsis thaliana clone 28451 mRNA, complete sequence.
GenBankBT0246910.0BT024691.1 Arabidopsis thaliana At1g46768 mRNA, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_564496.11e-109ethylene-responsive transcription factor RAP2-1
SwissprotQ8LC301e-111RAP21_ARATH; Ethylene-responsive transcription factor RAP2-1
TrEMBLD7KPW51e-92D7KPW5_ARALL; Putative uncharacterized protein
STRINGAT1G46768.11e-108(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. Maruyama K, et al.
    Identification of cold-inducible downstream genes of the Arabidopsis DREB1A/CBF3 transcriptional factor using two microarray systems.
    Plant J., 2004. 38(6): p. 982-93
  3. Zhang JZ,Creelman RA,Zhu JK
    From laboratory to field. Using information from Arabidopsis to engineer salt, cold, and drought tolerance in crops.
    Plant Physiol., 2004. 135(2): p. 615-21
  4. Zhang X, et al.
    Freezing-sensitive tomato has a functional CBF cold response pathway, but a CBF regulon that differs from that of freezing-tolerant Arabidopsis.
    Plant J., 2004. 39(6): p. 905-19
  5. Vogel JT,Zarka DG,Van Buskirk HA,Fowler SG,Thomashow MF
    Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis.
    Plant J., 2005. 41(2): p. 195-211
  6. Hannah MA,Heyer AG,Hincha DK
    A global survey of gene regulation during cold acclimation in Arabidopsis thaliana.
    PLoS Genet., 2005. 1(2): p. e26
  7. Kim S,Soltis PS,Wall K,Soltis DE
    Phylogeny and domain evolution in the APETALA2-like gene family.
    Mol. Biol. Evol., 2006. 23(1): p. 107-20
  8. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  9. Oono Y, et al.
    Monitoring expression profiles of Arabidopsis genes during cold acclimation and deacclimation using DNA microarrays.
    Funct. Integr. Genomics, 2006. 6(3): p. 212-34
  10. Xiong Y,Fei SZ
    Functional and phylogenetic analysis of a DREB/CBF-like gene in perennial ryegrass (Lolium perenne L.).
    Planta, 2006. 224(4): p. 878-88
  11. Benedict C,Geisler M,Trygg J,Huner N,Hurry V
    Consensus by democracy. Using meta-analyses of microarray and genomic data to model the cold acclimation signaling pathway in Arabidopsis.
    Plant Physiol., 2006. 141(4): p. 1219-32
  12. Willems G, et al.
    The genetic basis of zinc tolerance in the metallophyte Arabidopsis halleri ssp. halleri (Brassicaceae): an analysis of quantitative trait loci.
    Genetics, 2007. 176(1): p. 659-74
  13. Welling A,Palva ET
    Involvement of CBF transcription factors in winter hardiness in birch.
    Plant Physiol., 2008. 147(3): p. 1199-211
  14. Tsutsui T, et al.
    DEAR1, a transcriptional repressor of DREB protein that mediates plant defense and freezing stress responses in Arabidopsis.
    J. Plant Res., 2009. 122(6): p. 633-43
  15. Dong CJ,Liu JY
    The Arabidopsis EAR-motif-containing protein RAP2.1 functions as an active transcriptional repressor to keep stress responses under tight control.
    BMC Plant Biol., 2010. 10: p. 47
  16. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
  17. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
  18. Okamuro JK,Caster B,Villarroel R,Van Montagu M,Jofuku KD
    The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 1997. 94(13): p. 7076-81